Before one can answer the question of whether or not life has meaning, I think that it’s necessary to be clearer on what is encompassed by the word meaning.
If one intends that meaning be interpreted as “an inherent goal toward which one moves or is moved, and which is given to us consciously by ourselves or by another being at or before birth”, then I would have to say that there is no empirical evidence yet uncovered that life has any meaning. Life occurs, and it doesn’t have to have a purpose to occur. Rain also occurs. It has causes and effects, but it doesn’t have an inherent meaning. I would love to think that we are part of a greater dynamic in which our existence extends beyond death and has an inherent meaning, but I can’t yet attribute any such meaning to life.
If meaning signifies the prime motivators of our lives, I would say there are two biological imperatives: survive, and reproduce.
As for other connotations of meaning, I think that a person is free to give his life the meaning he chooses to give it.